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Kazuhiro Yoshikawa Selected Research

Neoplasms (Cancer)

2/2022T-cell responses and combined immunotherapy against human carbonic anhydrase 9-expressing mouse renal cell carcinoma.
1/2022Tumor-infiltrating FoxP3+ T cells are associated with poor prognosis in oral squamous cell carcinoma.
10/2021Improving function of cytotoxic T-lymphocytes by transforming growth factor-β inhibitor in oral squamous cell carcinoma.
8/2021Context-Specific Efficacy of Apalutamide Therapy in Preclinical Models of Pten-Deficient Prostate Cancer.
5/2021CD52 is a novel target for the treatment of FLT3-ITD-mutated myeloid leukemia.
12/2020Combining T-cell-based immunotherapy with venetoclax elicits synergistic cytotoxicity to B-cell lines in vitro.
6/2020Immune-checkpoint molecules on regulatory T-cells as a potential therapeutic target in head and neck squamous cell cancers.
10/2019Increased infiltration of CCR4-positive regulatory T cells in prostate cancer tissue is associated with a poor prognosis.
7/2019Targeting lactate dehydrogenase‑A promotes docetaxel‑induced cytotoxicity predominantly in castration‑resistant prostate cancer cells.
1/2019Systemic transduction of p16INK4a antitumor peptide inhibits lung metastasis of the MBT-2 bladder tumor cell line in mice.
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Kazuhiro Yoshikawa Research Topics

Disease

36Neoplasms (Cancer)
02/2022 - 10/2002
10Renal Cell Carcinoma (Grawitz Tumor)
02/2022 - 09/2003
10Prostatic Neoplasms (Prostate Cancer)
08/2021 - 04/2004
5Neoplasm Metastasis (Metastasis)
01/2019 - 09/2004
4Squamous Cell Carcinoma of Head and Neck
10/2021 - 05/2011
3Leukemia
05/2021 - 12/2004
3Urinary Bladder Neoplasms (Bladder Cancer)
01/2019 - 10/2002
3Moyamoya Disease (Moya-Moya Disease)
01/2018 - 11/2010
3Glioma (Gliomas)
12/2010 - 02/2003
2Squamous Cell Neoplasms (Squamous Cell Cancer)
06/2020 - 11/2017
2Edema (Dropsy)
01/2018 - 07/2017
2Adenocarcinoma
01/2015 - 10/2008
2Lymphoma (Lymphomas)
02/2013 - 12/2004
2Glioblastoma (Glioblastoma Multiforme)
12/2010 - 06/2008
2Brain Neoplasms (Brain Tumor)
06/2008 - 09/2005
2Sepsis (Septicemia)
01/2008 - 01/2006
1Severe Combined Immunodeficiency (Bare Lymphocyte Syndrome)
05/2021
1Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
05/2021
1Myeloid Leukemia (Leukemia, Myelocytic)
05/2021
1Membranoproliferative Glomerulonephritis (Membranoproliferative Glomerulonephritis, Type II)
01/2021
1B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia)
12/2020
1B-Cell Lymphoma (Lymphoma, B Cell)
12/2020
1Carcinoma (Carcinomatosis)
08/2020
1Body Weight (Weight, Body)
01/2019
1Retinoblastoma (Glioblastoma, Retinal)
01/2019
1Hypoalbuminemia
01/2018
1Hypokalemia
01/2018
1Hypoaldosteronism (Hyporeninemic Hypoaldosteronism)
01/2018
1Hypertension (High Blood Pressure)
01/2018
1Alkalosis
01/2018
1Proteinuria
01/2018
1Nephrotic Syndrome (Syndrome, Nephrotic)
01/2018
1Head and Neck Neoplasms (Head and Neck Cancer)
11/2017

Drug/Important Bio-Agent (IBA)

10Proteins (Proteins, Gene)FDA Link
12/2020 - 04/2006
8Peptides (Polypeptides)IBA
01/2019 - 09/2003
6AntigensIBA
11/2017 - 09/2003
4AntibodiesIBA
02/2022 - 07/2005
4Messenger RNA (mRNA)IBA
10/2021 - 10/2003
4Androgen Receptors (Androgen Receptor)IBA
08/2021 - 09/2014
4Biomarkers (Surrogate Marker)IBA
08/2020 - 07/2009
3Immune Checkpoint InhibitorsIBA
02/2022 - 03/2016
3Immunoglobulin G (IgG)IBA
01/2021 - 03/2006
3Monoclonal AntibodiesIBA
03/2016 - 07/2003
3Cyclin-Dependent Kinase Inhibitor p16IBA
02/2013 - 12/2004
3Wr-T peptideIBA
02/2013 - 06/2008
3Interferon-alpha (Interferon Alfa)IBA
09/2009 - 04/2006
2Cisplatin (Platino)FDA LinkGeneric
08/2020 - 11/2017
2Fluorouracil (Carac)FDA LinkGeneric
08/2020 - 11/2017
2Pharmaceutical PreparationsIBA
08/2020 - 01/2006
2Hormones (Hormone)IBA
10/2019 - 07/2019
2Retinoblastoma ProteinIBA
01/2019 - 02/2013
2Phosphoric Monoester Hydrolases (Phosphatases)IBA
11/2018 - 01/2015
2Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
11/2018 - 01/2013
2TensinsIBA
11/2018 - 01/2015
2Dacarbazine (DIC)FDA LinkGeneric
03/2016 - 01/2008
2AndrogensIBA
01/2015 - 09/2014
2Therapeutic UsesIBA
09/2014 - 11/2013
2epidermal growth factor receptor VIIIIBA
12/2010 - 07/2003
2ErbB Receptors (EGF Receptor)IBA
12/2010 - 07/2003
2Microphthalmia-Associated Transcription FactorIBA
09/2009 - 04/2007
2K cadherinIBA
09/2004 - 10/2003
1Cyclophosphamide (Cytoxan)FDA LinkGeneric
02/2022
1Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA
02/2022
1Axitinib (AG 013736)IBA
02/2022
1Carbonic Anhydrases (Carbonic Anhydrase)IBA
02/2022
1Transforming Growth Factors (Transforming Growth Factor)IBA
10/2021
1apalutamideIBA
08/2021
1Androgen Antagonists (Antiandrogens)IBA
08/2021
1Proline (L-Proline)FDA Link
08/2021
1Alemtuzumab (Campath)FDA Link
05/2021
1fms-Like Tyrosine Kinase 3IBA
05/2021
1venetoclaxIBA
12/2020
1Immune Checkpoint ProteinsIBA
06/2020
1LigandsIBA
06/2020
1Galectins (Galectin)IBA
06/2020
1CC ChemokinesIBA
10/2019
1Docetaxel (Taxotere)FDA Link
07/2019
1Lactic Acid (Lactate)FDA LinkGeneric
07/2019
1L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA
07/2019
1Antisense OligonucleotidesIBA
01/2019
1Potassium Sparing DiureticsIBA
01/2018
1proenkephalinIBA
01/2018
1Spironolactone (Aldactone)FDA LinkGeneric
01/2018
1SteroidsIBA
01/2018
1Triamterene (Dyrenium)FDA LinkGeneric
01/2018
1Amiloride (Midamor)FDA LinkGeneric
01/2018
1Epithelial Sodium ChannelsIBA
01/2018
1Neoplasm Antigens (Tumor Antigens)IBA
11/2017
1cytomegalovirus matrix protein 65kDaIBA
11/2017

Therapy/Procedure

20Therapeutics
02/2022 - 12/2004
9Immunotherapy
02/2022 - 05/2008
6Castration
08/2021 - 09/2014
2Drug Therapy (Chemotherapy)
11/2017 - 11/2014
2Aftercare (After-Treatment)
03/2016 - 10/2002
2Chemoprevention
05/2015 - 01/2015
2Lasers (Laser)
01/2015 - 07/2009
2Renal Dialysis (Hemodialysis)
12/2013 - 01/2011
1Prostatectomy (Retropubic Prostatectomy)
10/2019
1Gastrectomy
01/2018
1Immunomodulation
11/2017